I spoke with a hedge-fund partner yesterday.

I spoke with a hedge-fund partner yesterday. His cardiologist told him to cut meat and animal fats because his APOB and LP(a) were high. He was terrified. His father died of a heart attack. But here’s the reality few clinicians explain as to why those numbers are shaky ground for judgment: 1. Measurement is NOT the same as Truth Both APOB and LP(a) are plagued by testing inconsistencies. LP(a) assays often misread because particle size varies. APOB testing isn’t standardized globally. Two labs, same patient but different “risk.” 2. Not the Golden Marker Yes, APOB correlates with risk. But major studies show it’s not clearly superior to LDL-C. Even the 2021 ESC guidelines don’t recommend replacing LDL-C outright. For most people, the difference is statistical, not clinical. 3. Context Matters These markers only matter when they disagree with other lipids or in metabolic syndrome, diabetes, or high triglycerides. Otherwise, APOB, LDL-C, and non-HDL-C rise and fall together. Even more telling is a U-shaped curve links APOB to mortality. Too high or too low both predict risk. 4. No Proof That Lowering Them Saves Lives For LP(a), we still don’t have intervention trials showing that reducing it lowers events. APOB is a marker, not a confirmed target. I don't need to remind you that correlation is not causation. 5. The Bigger Picture Heart disease isn’t caused by a single molecule. Inflammation, insulin resistance, mineral balance, circadian rhythm, and chronic stress all shape vascular health more than one blood test ever could. 6. Genetics is NOT the same as Fate LP(a) is mostly genetic. You can’t “biohack” it away with diet or supplements. And the drugs that claim to do it? We have no long-term outcome data yet. So the bottom Line is that sure, numbers like APOB and LP(a) can inform But they should never dictate. True cardiovascular resilience comes from fixing your biological terrain and restoring order by focusing on metabolic stability, inflammation control, mitochondrial health, testosterone, sleep, and sunlight. Because guess what? You don’t outsmart biology by chasing numbers, you rebuild it by restoring order.